In vivo TNF- inhibition ameliorates cardiac mitochondrial dysfunction, oxidative stress, and apoptosis in experimental heart failure
نویسندگان
چکیده
Gordon W. Moe, Jose Marin-Garcia, Andrea Konig, Michael Goldenthal, Xiangru Lu, and Qingping Feng Terrence Donnelly Heart Program, St. Michael’s Hospital, University of Toronto, Toronto, Ontario, Canada M5B 1W8; The Molecular Cardiology Institute, Highland Park, New Jersey 08903; and Departments of Medicine, Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada NGA 4G5
منابع مشابه
In vivo TNF-alpha inhibition ameliorates cardiac mitochondrial dysfunction, oxidative stress, and apoptosis in experimental heart failure.
Heart failure is associated with increased myocardial expression of TNF-alpha. However, the role of TNF-alpha in the development of heart failure is not fully understood. In the present study, we investigated the contribution of TNF-alpha to myocardial mitochondrial dysfunction, oxidative stress, and apoptosis in a unique dog model of heart failure characterized by an activation of all of these...
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تاریخ انتشار 2004